Coumarins and derivatives
eMolecules 2,2'-(Octylazanediyl)diethanol | 15520-05-5 | MFCD06252160 | 1g
Combi-Blocks, Inc. | 2,2'-(Octylazanediyl)diethanol | 1g | 603129908 | HA-4628 | 95.000 | 15520-05-5 | MFCD06252160 | 217.353 | C12H27NO2
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Cayman Chemical 7-EthoxycoumarIn 250mg
A CYP450 substrate; undergoes O-deethylation by various CYP isoforms; has been used in the functional characterization of CYPs in cats, rats, and isolated human cornea
Sigma Aldrich Fine Chemicals Biosciences 7-Ethoxycoumarin | 31005-02-4 | MFCD00006877 | 100MG
7-Ethoxycoumarin | Purity: >=99.45% (HPLC) | Mol Wt: 190.2 | 31005-02-4 | MFCD00006877 | 100MG
Apexbio Technology LLC Esculin 531-75-9 20mg
Esculin (CAS 531-75-9) is a coumarin glucoside isolated from the bark of Aesculus hippocastanum It functions primarily as a -glucosidase substrate hydrolyzing to esculetin and glucose upon enzymatic action Esculin s fluorescence properties make it valuable in assays monitoring -glucosidase activity in microbiological and biochemical research Additionally its antioxidant and vasoprotective effects have supported investigations into microcirculatory disorders and oxidative stress-related models Esculin is soluble in hot ethanol methanol pyridine ethyl acetate and acetic acid and should be stored in sealed cool and dry conditions
Apexbio Technology LLC Coumarin 91-64-5 50mg
Coumarin (91-64-5) is a small-molecule inhibitor targeting cytochrome P450 isoforms It is designed to modulate enzyme activity thereby regulating metabolic pathways Coumarin exerts its biological activity primarily through inhibition of cytochrome P450 enzymes In in vitro studies coumarin demonstrates enzyme inhibitory activity with an IC50 range of approximately 0 5 to 10 M depending on the isoform and experimental system Based on these pharmacological properties coumarin holds research potential in anticoagulant anti-inflammatory and anticancer agent discovery
Apexbio Technology LLC HX 531 188844-34-0 10mg
HX 531 (CAS 188844-34-0) is a small-molecule antagonist targeting the retinoid X receptor (RXR) It modulates RXR-associated signaling pathways thereby influencing both tumorigenic and metabolic biological processes HX 531 exerts its biological activity by antagonizing RXR which results in cell cycle arrest at the G0/G1 phase and modulation of leptin-dependent pathways and the p53-p21Cip1 signaling axis In rodent models HX 531 demonstrates an inhibitory activity with an IC50 value of approximately 18 nM Based on these pharmacological properties HX 531 holds research potential in the study of metabolic disorders obesity diabetes and cancer biology
Apexbio Technology LLC 3-Carboxy-7-Hydroxycoumarin 779-27-1 1g
3-Carboxy-7-Hydroxycoumarin (CAS 779-27-1) is a coumarin-based fluorescent molecule It is characterized by blue fluorescence emission upon excitation with ultraviolet light Structurally it features a carboxyl group that enables conjugation via carbodiimide activation (e g EDAC-mediated formation of succinimidyl ester intermediates) allowing covalent attachment to amine-containing residues in proteins and nucleic acids Based on these properties 3-Carboxy-7-Hydroxycoumarin is commonly employed in biochemical research for fluorescent labeling including analysis of protein protein interactions nucleic acid visualization and biomolecule detection assays
Apexbio Technology LLC Coumarin 6 38215-36-0 100mg
Coumarin 6 (CAS 38215-36-0) is a fluorescent dye utilized primarily as a tracer in biomedical research for particulate drug delivery systems Coumarin 6 facilitates the visualization and analysis of particle distribution trafficking and cellular uptake processes in vitro and in vivo It is applied to study biological mechanisms related to transport and localization of therapeutic molecules and their interactions with cellular compartments Based on these properties Coumarin 6 holds research potential in evaluating drug delivery dynamics cellular internalization pathways pharmacokinetic behavior and disease-related investigations
Apexbio Technology LLC 3-Nitrocoumarin 28448-04-6 5mg
3-Nitrocoumarin (CAS 28448-04-6) is a selective inhibitor of phospholipase C- (PLC- ) an enzyme involved in cellular signal transduction through the hydrolysis of membrane phospholipids and subsequent generation of secondary messengers By suppressing PLC- catalytic activity 3-Nitrocoumarin disrupts related intracellular signaling pathways thereby enabling investigation of PLC- -mediated mechanisms in various physiological and pathological contexts This compound is widely utilized in studies focused on elucidating the roles of PLC- in disease models and fundamental biomedical research
Apexbio Technology LLC 3-Carboxy-7-Hydroxycoumarin 779-27-1 100mg
3-Carboxy-7-Hydroxycoumarin (CAS 779-27-1) is a coumarin-based fluorescent molecule It is characterized by blue fluorescence emission upon excitation with ultraviolet light Structurally it features a carboxyl group that enables conjugation via carbodiimide activation (e g EDAC-mediated formation of succinimidyl ester intermediates) allowing covalent attachment to amine-containing residues in proteins and nucleic acids Based on these properties 3-Carboxy-7-Hydroxycoumarin is commonly employed in biochemical research for fluorescent labeling including analysis of protein protein interactions nucleic acid visualization and biomolecule detection assays
Apexbio Technology LLC 3-Carboxy-7-Hydroxycoumarin 779-27-1 250mg
3-Carboxy-7-Hydroxycoumarin (CAS 779-27-1) is a coumarin-based fluorescent molecule It is characterized by blue fluorescence emission upon excitation with ultraviolet light Structurally it features a carboxyl group that enables conjugation via carbodiimide activation (e g EDAC-mediated formation of succinimidyl ester intermediates) allowing covalent attachment to amine-containing residues in proteins and nucleic acids Based on these properties 3-Carboxy-7-Hydroxycoumarin is commonly employed in biochemical research for fluorescent labeling including analysis of protein protein interactions nucleic acid visualization and biomolecule detection assays
Apexbio Technology LLC Palomid 529 914913-88-5 10mg
Palomid 529 (CAS 914913-88-5) is a small-molecule inhibitor of the PI3K/Akt/mTOR signaling pathway targeting both TORC1 and TORC2 complexes It exhibits potent anti-proliferative activity in the NCI-60 cell line panel with GI50 values below 35 M In endothelial cell assays Palomid 529 inhibits VEGF- and bFGF-induced proliferation with IC50 values of 20 nM and 30 nM respectively The PI3K/Akt/mTOR pathway is implicated in tumor cell survival proliferation angiogenesis and resistance to apoptosis Palomid 529 has also demonstrated the ability to suppress radiation-induced expression of Id-1 VEGF MMP-2 and MMP-9 expanding its utility in studies of cancer biology and radiotherapy sensitization